Health Sciences Recharges

Pharmacology Service

The Laboratory Pharmacology Shared Resource provides in vitro tissue culture-based and in vivo mouse-based testing of the efficacy and pharmacology of novel anti-cancer drugs and drug delivery systems. Specific tissue culture-based assays include molecular engineering of tumor cell lines to express marker proteins, transwell and in vitro scratch assays of migration, western blot analysis and qRT-PCR analysis of drug included changes in individual mRNAs and proteins. In vivo assay include assays of drug effect against human tumor xenografts grown in immunodeficient mice or murine tumors grown in inbred mice, and assessment of drug pharmacokinetics in mice.

Last Update: 1/19/16

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